Teams had been playing 76 in-division games. That total is now down to 52 (13 games and four series against each foe).
Non-divisional intraleague games (for example, NL East vs. NL Central) is now a tidy 64 (32 home and 32 away) instead of 66. Each team will have seven games against four chosen opponents and six games against the other six teams fitting this criteria.
Interleague play gets the massive increase. There used to be 20 of these games and now each team has 46. This includes a home-and-home series between "natural rivals" and then one series (seven home, seven road for each team) against the remaining 14 teams in the other league