Colts at Falcons (-2½, 44½): Indianapolis is on a 5-1 ATS run, while Atlanta is on a 3-10 ATS skid, including 1-5 at home. The Colts are on a 4-0 over run. Edge: Colts and slight to over.
Packers (-5, 37½) at Panthers: Green Bay has lost and failed to cover two straight after a 3-0 ATS run. Carolina has covered two of three but is only 3-9-2 ATS this season. Edge: Slight to Packers
Browns (-3, 40½) at Texans: Cleveland is 1-5 ATS on the road this season. The Browns are 2-1 straight-up with quarterback Joe Flacco (1-1-1 ATS). Houston is on a 3-5 ATS skid. Edge: Slight to Browns.
Seahawks (-3½, 41½) at Titans: Diverging trends for Seattle, which is on a 4-1 ATS run as a favorite but is on a 1-4 ATS skid on the road. Tennessee is on a 3-7 ATS skid. The Seahawks are on a 5-1 under run on the road. Edge: Slight to Seahawks.
Commanders at Jets (-3, 37½): Washington has lost five in a row and failed to cover the last four, but New York has lost and failed to cover six of seven. The Jets are on a 7-2 under run. Edge: Slight to under.
Lions (-3, 47) at Vikings: Detroit has covered five straight in this series despite only winning two of the games. The Lions are also 5-2 ATS on the road this season. Minnesota is on an 0-2-1 ATS skid. The over is on a 5-1 run in this series. Edge: Over and slight to Lions.
Jaguars at Buccaneers (-3, 41½): Jacksonville has lost and failed to cover three in a row after a 7-1 ATS run. Tampa Bay has won three straight (2-1 ATS) and is on a 4-0 over run. Edge: Slight to over.
Cowboys at Dolphins (-1, 50½): Despite 10-4 record, Dallas is on a 2-4 ATS skid on the road. Miami is 5-2 ATS at home this season and 9-5 ATS overall. Edge: Slight to Dolphins.
Cardinals at Bears (-4, 43½): Arizona has covered two straight on the road with quarterback Kyler Murray back, but Chicago is on a 4-0-2 ATS run. The Cardinals are on a 6-1 under run on the road this season, and the Bears are on a 6-1 under run overall. Edge: Under and slight to Bears.
Patriots at Broncos (-7, 34½): New England is 3-10-1 ATS this season but is 1-0-1 in its last two. Denver has won six of eight SU but is only 2-4 ATS as a favorite this season. The Patriots were on a 9-1 under run before two straight overs, while the Broncos are on a 7-2 under run. Edge: Under and slight to Broncos.
